What is the difference between Prototype and Wireframe?

A prototype is interactive whereas Wireframe is not.

A wireframe is a low-fidelity representation of a product’s design.

A prototype is a mid- to high-fidelity representation of the final product

wireframes shows initial desgin and the flow of the information through out the system

Prototypes are the advanced version of the wireframes, where it shows more details and information about the system. 

Wireframes are the first level of designs to understand the flow concept level through research and "Prototypes" are also known as High Fidelity in which designs are made a look-alike of real application which is created using HTML, CSS, Javascript/Jquery

Wireframing is a structure of information and low fidelity visualization of the user interphase represented with very simple graphics/Sketch.

Prototype involves generating simple interactive experience may be by using HTML, this will have resemblance to the final product only in terms of interaction.

Wireframes are genrally the Blue-prints of the thoughts or the gathered information depiction for better understand.

• Easy to change 
• Easy to create
• They can be hand-drawn or you may use any application for it
• Used for initial reference and understanding of the Requirement

Prototypes as the Screen navigation with Designed screen (Colors and buttons). It is to showcase the Stake holders that how the screen navigation is going to be and how it will look on the Target devices after the completion of the complete feature implementation

• UX demonstration on the target device
• Stake-holders get the glimpse of product before it too late
• Protypyes can be created using various tools such as Proto.io