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LEED is now on version4 where as version3 (2009) is still valid.
In v3 there is a credit enhanced refrigerant management which says that the suppression systems should not use ozone depleting substances such as CFCs and HCFCs or halons.EPA website has the alternatives for these materials.
LEED v4 does not mention anything in EAc4 about this.But it would be better to avoid these .
Other than that I think there is no other restriction as far as LEED is concerned.
Dear Sharif,
It is a prerequisite in LEED not to use CFCs, HCFCs and Halons in fire suppression systems and HVAC. In my opinoin using CO2 would be acceptable as it is an alternative to CFCs and HCFCs. Furthermore, LEED also recommend using refrigerants having an ODP of zero and GWP of less than and in this case CO2 fulfils the requirements as its ODP is zero and GWP is1.