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Sorry I'm not a specialist
Its hard to say sometimes we could remove vocals completely sometimes not. Its hard to do it , because anything associated with that given vocals for example instruments could be ruined or even became asynchronous. Lets take for instance , the stereo recording. You can adjust the singer's voice , the instrument's sound or even add sounds that were not before. Also, the Mp3 vocals , you cannot remove unless you reduces its level from great quality to good quality.
I believe its hard to say there is and there isn't, because of the low quality that would be gained from such processing.
There are several , ways that we could choose from , and regarding which is best it depends on the type of processing to be done.
1- Removing background noise
2- low frequencies
3- Compressing dynamics
and the list goes on...
