In body language terms, what does it mean when someone talks to you with their arms crossed?

B- The person is feeling uncomfortable

Because this is evidence that the person is trying to protect himself

Hand crossing can be interpreted as both disrespectful and offensive; so answers B & C can apply

It means he is trying  to protect himself by being invisible ,this show a weakness in his personality. 

c-The person is showing disinterest and trying to block communicationThere are times when someone hears you with attention with his/her arms closed but most of the time, it is mostly because the person is trying to block communication and showing arrogance. 

I think B&C 

Thank you for your invitation

the answer is B

crossing arms is a protective gesture also it means lack of trust and anxiety.

so yes they are uncomfortable.  

Is this a multiple choice "test" ? are you gauging right responses ? do you have a pre determined answer ?

Is this a multiple choice “test” ? And what’s your predetermined answer ?

Q. In body language terms, what does it mean when someone talks to you with their arms crossed?

Answer – Option E. On it’s own a single gesture lacks meaningful information.

Body language is highly context dependent and idiosyncratic.

Is the room cold ? Does he/she feel cold ? What are they wearing ?

What’s the pitch & pace of their voice ?

Do they speak deliberately ?

How are their feet placed ? and torso ?

What about eye contact ? How is it maintained ?

While the arms are cross how big are their hand gestures ?

Where are they from ? and in what culture did they grow up in ?

In Short – How should we know, there’s insufficient information to draw a meaningful conclusion.

However if you want the Mickey Mouse Answers: B & C