ابدأ بالتواصل مع الأشخاص وتبادل معارفك المهنية

أنشئ حسابًا أو سجّل الدخول للانضمام إلى مجتمعك المهني.

متابعة

How to enhance dissolution profile of a poorly water soluble API?

user-image
تم إضافة السؤال من قبل Muhammad Fayyaz , Plant Manager , Pearl pharmaceutical
تاريخ النشر: 2017/06/30
venkatarao  polina
من قبل venkatarao polina , Head Of Operations , DEEP C BLUE CO., LTD.

To improve the solubility with nanocrystalization by antisolvent.

Seyyed Amir Siadati
من قبل Seyyed Amir Siadati , Iran , Tofigh Daru Research & Engineering Pharmaceutical Company

1. you could heat (if the heat does not decompose the matter) or ultrasound the sample solution.

2. you could decrease the concentration of the test solution.

3. or if possible, you could reject the solubility test due to certificate, and then say the project manager to make a new "poly morph" (or a powder with smaller crystals) of the matter by recrystallization.

mohammed irfan
من قبل mohammed irfan , senior microbiologist , chandra labs

We have to check its it's solubility on 0.0001N HCl if not then 0.001N HCl,then 0.01 N HCl and finally 0.1N HCl if

jayasutha iyyapaazham
من قبل jayasutha iyyapaazham , medical Auditor , london hospital

SALT FORM OF DRUG,COSOLVENT,SOLID DISPERSION

المزيد من الأسئلة المماثلة