May the determination of Unknown cost of R&D Projects be a mitigation of risk factor?

A R&D project is an exploratory high-risk investment activity and has potential management flexibility.
Risk Factors in R&D projects should be analyzed since the failure risk probability of R&D projects is considerably high, compared with other projects.
Stating and analyzing these risks clearly will lead to more effective decision making in various steps of the R&D project.
Therefore, risk management in R&D projects affects the project considerably but it is hard to quantify risk with very little past information available.
Through many preliminary studies, risks can be categorized as follows; market related risks, technology related risks, environment related risks, organization related risks.
In Fact The decision to start a Research and Development (R&D) project is one of the most challenging firm decision problems.
R&D projects usually take time to complete, their investments are irreversible and therefore represent sunk costs and above all, they are highly uncertain.
Uknown Cost of R&D if it can be determined in advance it can be a big mitigation of the most important risk factor, the market related risks.
In a recent study it has been found that according to the relation matrix between R&D project success factors and risk indexes, risk priority list can be obtained.
Then, risk features of various stages are analyzed.
Finally, real options are embedded into various stages of R&D project by the risk features.
In order to effectively manage R&D risk in a dynamic cycle, the steps above should be carried out repeatedly.

I am talking about applied and empirical research projects.
I know project management methodology is not applied on basic and fundamental research because there is no time limit.
However in scale-up of process or process design and development, usually we do not care about expensed engineering.
Expensed engineering is cost of project before initiation.
When process is leased out or sale we do not consider the R&D expenses.
There are many factors for determination of cost of R&D project.
Papers & Presentation in Project Management; Cost Management S.
Burhanuddin Abdali, Askari Begum, M.Adil and Z.A.Dhakan, “Cost Estimation for R&D projects in PCSIR, Karachi”, paper has accepted for 26th IPMA World Congress, Greece, 29-31 Oct.
2012, , Greece S.
Buarhanuddin Abdali, Askari Begum and M.
Adil, “To determine risk factors and their probable impacts on R&D projects of PCSIR, Labs.
Kar.
Pak” abstract has accepted at 14th PMI-AGC International Conference, Bahrain, 28-30 January 2013 Regards Syed Burhanuddin Abdali