What is the Optimum Model for Distribution of Goods which have operation in multiple country?

While a multi layered distribution works well for goods distribution within countries in Europe, it becomes more complex if we consider global distribution. Since factors that effect the supply chain and its respective variables differ, a standard optimized model is not so practical to arrive at. Instead, an individual analysis could be carried out to assess focussed variations in the supply chain and optimization can be achieved within the selected transit.