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It depends on who you ask.
Some people say that emotions are the fundamental human weaknesses, where others argue that it is the exact opposite.
Others say inconsistences are the issue, where opposition will say being consistent is boring and lacks the excitement of life.
Also, some might say the memory is a weak aspect of the human experience, but then forgetting a bad experience or a tragic incident is important for the continuance of life.
I think the fundamental human weakness is by far the fact that we are humans, we are supposed to be faulty and weak in different areas, that is what makes life the roller coaster it is.