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Sit at an adjustable desk specially designed for use with computers.
Have the computer monitor (screen) either at eye level or slightly lower.
Have your keyboard at a height that lets your elbows rest comfortably at your sides. Your forearms should be roughly parallel with the floor and level with the keyboard.
Adjust your chair so that your feet rest flat on the floor, or use a footstool.
Take frequent short breaks and go for a walk, or do stretching exercises at your desk. Stand often.