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One of the biggest disadvantage of in-row cooling is the routing of chilled water/refrigerant piping within the DATA hall. However, there are smart system such as leak detection to identify threats due to leakages in nuisance.
I can only think of2 situations where you should not use in-row cooling.... if the rack capacity is too low, in that case the high initial cost of multiple in-row cooling will not be justified or if the white space is too limited and cannot spare the extra space needed for the cooling units