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1) Increase in the number of chromosomes: to become instead of.2) decrease in the number of chromosomes: to become instead of.3) a defect in the installation of a pigments increase or decrease in the length of the result was part of a chromosome, or add it to another chromosome called (Trans Location) ie: lack of disengagement (Nondisjunction) so that sexual cell of any of the father and the mother contains chromosomes instead of, or have instead of, so that the final number of or instead of chromosomes, a normal number of human cell, non-sexual, and this is happening in the reductive cleavage of the testis or ovary, and Fadlallah capacity mercy that these embryos abort automatically, rarely someone living fetus.But this imbalance images including:The excess number (tri-dye) TriosomyAnd this imbalance is happening in the autosomes (Autosomal) or in the sexual chromosomes (X Chromosome) Examples of chromosomes triple physical (Triosom y) the pair No. cause disease (Mongolism