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SELECTION OF ANTIMICROBIAL AGENTS }Selection of the most appropriate antimicrobial agent requires knowl- edge of :A. Empiric therapy prior to organism identification 1.The acutely ill patient.2.Selecting a drug.B. Laboratory methods of identificationC .The effect of the site of infection on therapy (Blood-brain barrier, prostate )
E. Status of the patient
1.Immune system: (Elimination of infecting organisms from the body depends on an intact immune system. ) 2.Renal dysfunction: Poorkidney function (10% or less of normal) causes accumulation of antibiotics that are ordinarily eliminated by this route. 3.Hepatic dysfunction: Antibiotics that are concentrated or elimi- nated by the liver (for example, erythromycin, 4.Poor Perfusion: Decreased circulation to an anatomic 5.Pregnancy:All antibiotics cross the placenta. 6.Lactation: 7.Age: neonate ,childF. Safety of the agent
G. Cost of therapy
