How can I select two different columns like column A and column E in Excel without the concentric columns?

If you want to select a non-contiguous cells, rows or columns just simply hold the CTRL and click.

Press Ctlr (Control Button) than Click on Column A and E

hold on ctrl and select colunm A, then write comma (,) and select column E while holding Ctrl and press enter you will get the answer.

click on column A then hold press on ctrl and then select the other column

Select while pressing ctrl key 

 Select by clicking the Column A with mouse Cursor then hold the CTRL then select Column E,D,F.

holding ctrl  + select which columns you want 

Very Simple select by clicking the Colum A with mouse Cursor then hold the CTRL then select Colum E,D,F whetever you Want by mouse cursor

Simply use Ctrl key, just hold ctrl key and select as much different column as you need