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What do you know about Krebs cycle?

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Question added by Deleted user
Date Posted: 2015/06/23
Duaa Ahmad Idris Elhaj
by Duaa Ahmad Idris Elhaj , Master research student , Al-Neelian University

 is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetyl-CoA derivedfrom carbohydratesfats and proteins into carbon dioxide and chemical energy in the form of guanosine triphosphate (GTP). In addition, the cycle provides precursors of certain amino acids as well as the reducing agentNADH that is used in numerous other biochemical reactions. 

Deleted user
by Deleted user

The Krebs cycle (or citric acid cycle) is a part of cellular respiration. Named after Hans Krebs, it is a series of chemical reactions used by all aerobic organisms to generate energy. Its importance to many biochemical pathways suggests that it was one of the earliest parts of cellular metabolism to evolve

 

 

Razaq Lawal
by Razaq Lawal , Quality Control/production manager , Things Remembered Nigeria Limited

it is also known as citric acid cycle or tricarboxylic acid (TCA) cycle is a series of chemical reaction used by all aerobic organisms to release stored energy through the oxidation of acetyl ,derived from carbohydrates, fats and proteins into carbondioxides and chemical energy in the form of ATP (adenosine triphosphate).

Sohail Khan
by Sohail Khan , Part-time Chemical Pathologist , Indus Hospital

Krebs Cycle is the final and common pathway located in the mitocondria  for the oxidative  metabolism of carbohydrates , lipids and proteins for the release of free energy from these compounds.

mohammed almohtaseb
by mohammed almohtaseb , Distributors Regional Manager , TotalEnergies

The Krebs Cycle is the central metabolic pathway in all aerobic organisms. The cycle is a series of eight reactions that occur in the mitochondrion. These reactions take a two carbon molecule (acetate) and completely oxidize it to carbon dioxide. The cycle is summarized in the following chemical equation: acetyl CoA +3 NAD + FAD + ADP + HPO4-2 --------------->2 CO2 + CoA +3 NADH+ + FADH+ + ATP,,, according to google ! I don't understand anything ð

Summy Yadav
by Summy Yadav , Teaching Associate , Ahmedabad University

Krebs cycle or citric acid cycle was discovered by H.A Kreb. This cycle takes place in matrix of mitochondria and also known as TCA (tricarboxylic acid) cycle. A series of chemical reactions to release stored energy in form of ATP (adenosine triphosphate) by oxidation of acetyl CoA derived from cabohydrates and fats. The net result of krebs cycle is that for each acetyl group entering the cycle as Acetyl CoA tao molecules of CO2 are produced.

lloyd mark reyes
by lloyd mark reyes , SERVICE CREW

The citric acid cycle – also known as the tricarboxylic acid (TCA) cycle or the Krebs cycle

ABDUL BASITH AZHAKAN KANDATHIL
by ABDUL BASITH AZHAKAN KANDATHIL , Sales engineer , Yanama trading company

A series of enzymatic reactions in aerobic organisms involving oxidative metabolism of acetyl units and producing high energy phosphate compounds such as ATP, which serve as the main source of cellular energy. Also called citricacid cycle, tricarboxylic acid cycle.

Ibrahim  Mohamed Ali
by Ibrahim Mohamed Ali , طبيب بيطرى مجند , وحدة البان القصاصين فوج انتاج الحيواني الجيش التاني الميدانى القوات المسلحة المصرية

is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetyl-CoA derivedfrom carbohydratesfats and proteins into carbon dioxide and chemical energy in the form of guanosine triphosphate (GTP)

Fathy Mahmoud Nabih Wallash
by Fathy Mahmoud Nabih Wallash , Quality Management Director , Alromansiah restaurant co

 

Organisms derive the majority of their energy from the Kreb's Cycle, also known as the TCA cycle. The Kreb's Cycle is an aerobic process consisting of eight definite steps. In order to enter the Kreb's Cycle pyruvate must first be converted into Acetyl-CoA by pyruvate dehydrogenase complex found in the mitochondria.

Steps

In order for pyruvate from glycolysis to enter the Kreb's Cycle it must first be converted into acetyl-CoA by the pyruvate dehydrogenase complex which is an oxidative process wherein NADH and CO2 are formed.  Another source of acetyl-CoA is beta oxidation of fatty acids.

  1. Acetyl-CoA enters Kreb Cycle when it is joined to oxaloacetate by citrate synthase to produce citrate. This process requires the input of water. Oxaloacetate is the final metabolite of the Kreb Cycle and it joins again to start the cycle over again, hence the name Kreb's Cycle. This is known as the committed step
  2. Citrate is then converted into isocitrate by the enzyme aconitase. This is accomplished by the removal and addition of water to yield an isomer.
  3. Isocitrate is converted into alpha-ketogluterate by isocitrate dehydrogenase. The byproducts of which are NADH and CO2.
  4. Apha-ketogluterate is then converted into succynl-CoA by alpha-ketogluterate dehydrogenase. NADH and CO2 are once again produced.
  5. Succynl-CoA is then converted into succinate by succynl-CoA synthetase which yields one ATP per succynl-CoA.
  6. Succinate coverts into fumerate by way of the enzyme succinate dehydrogenase and [FAD] is reduced to [FADH2] which is a prosthetic group of succinate dehydrogenase. Succinate dehydrogenase is a direct part of the ETC.  It is also known as electron carrier II.
  7. Fumerate is then converted to malate by hydration with the use of fumerase. 
  8. Malate is converted into oxaloacetate by malate dehydrogenase the byproducts of which are NADH.

Deleted user
by Deleted user

Also known as Citric Acid cycle, is a part of cellular respiration...It is a series of chemical reactions used by all aerobic organisms to generate energy.

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