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that is a good open and general question , I liked it.
I think focus on Opportunities whatever Big or Small, is the most important, the word FOCUS on Opportunity .
but classifying if it is towards getting Big or Small one, maybe depends on the capabilities of the organisation, Team, Sales person, and Funds /or in other Words COST OF Sales.
as what could be the point focus on Big Op. while Profitability could be Minimal.
anyway the Most important is Focus , Sell Sell, Sell .