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لماذا يظهر بروتين بنس جونس (bence jones)في بول المرضى المصابين بمرض؟

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Question added by سماء محمد وهيب عارف sidr , متدرب بقسم التحاليل الطبية , مستشفى البشير
Date Posted: 2013/09/17
Nadia AL-Jumaili
by Nadia AL-Jumaili , مدير مختبر وحدة الكلية الصناعية في مستشفى الكرامة , وزارة اصحة

بروتين يظهر في البول على شكل راسب ابيض عند تسخين البول لدرجة 60 مئوية ويدل عن وجود سرطان multiple myeloma ويعزز هذا الفحص باجراء الترحيل الكهربائي لبروتينات الدم معطيا شكل حرف ام بالانكليزي ويعرف ب M-band

Deleted user
by Deleted user

بسبب انتاج بروتين غير سليم يضهر على شكل قطعة احادية النسيله او على شكل سلسله خفيفة

zuhair yagoub
by zuhair yagoub , Omdurman-sudan , Abuseid clinic medical center

Itis important to diagnosis of multiple myelloma(B cell lymphoma), lymphoblastic leukemia, some bones diseases. itis apper in urine as low molecular weight protein.

Fathi Al-dissoki Ebrahim
by Fathi Al-dissoki Ebrahim , فنى تحاليل طبية / درجة ثانية , مديرية الصحة بالدقهلية - الادارة الصحية بشربين

يستخدم بشكل أساسي كاختبار أولي في الكشف عن بروتينات السلاسل الخفيفة من نوع كابا فى البول في حالات  الورم النقوي المتعدد و فى حالات الاورام الليمفاويه  Lymphoma او سرطان الدم Leukemia

سماء محمد وهيب عارف sidr
by سماء محمد وهيب عارف sidr , متدرب بقسم التحاليل الطبية , مستشفى البشير

 Bence-Jones protein in urine  used mainly to diagnose and monitor multiple myeloma, a blood cancer. An abnormal Bence-Jones test result is also linked with malignant lymphomas, which are cancers of the lymphatic system

Waleed Libda
by Waleed Libda , S.Medical Technologist , Weyburn General Hospital

Bence Jones Protein Test

Definition

Bence Jones proteins are small proteins (light chains of immunoblobulin) found in the urine. Testing for these proteins is done to diagnose and monitor multiple myeloma and other similar diseases.

Purpose

Bence Jones proteins are considered the first tumor marker. A tumor marker is a substance, made by the body, that is linked to a certain cancer, or malignancy. Bence Jones proteins are made by plasma cells, a type of white blood cell. The presence of these proteins in a person's urine is associated with a malignancy of plasma cells.

Multiple myeloma, a tumor of plasma cells, is the disease most often linked with Bence Jones proteins. The amount of Bence Jones proteins in the urine indicates how much tumor is present. Physicians use Bence Jones proteins testing to diagnose the disease as well as to check how well the disease is responding to treatment.

Description

Urine is the best specimen in which to look for Bence Jones proteins. Proteins are usually too large to move through a healthy kidney, from the blood into the urine. Bence Jones proteins are an exception. They are small enough to move quickly and easily through the kidney into the urine.

A routine urinalysis will not detect Bence Jones proteins. There are several methods used by laboratories to detect and measure these proteins. The classic Bence Jones reaction involves heating urine to140°F (60°C). At this temperature, the Bence Jones proteins will clump. The clumping disappears if the urine is further heated to boiling and reappears when the urine is cooled. Other clumping procedures using salts, acids, and other chemicals are also used to detect these proteins. These types of test will reveal whether or not Bence Jones proteins are present, but not how much is present.

A more complex procedure is done to measure the exact amount of Bence Jones proteins. This procedure—immunoelectrophoresis—is usually done on urine that has been collected for24-hours.

Preparation

Urine is usually collected throughout a24-hour time period. A person is given a large container in which to collect the urine. The urine should be refrigerated until it is brought to the laboratory or physician's office.

Normal results

Bence Jones proteins normally are not present in the urine.

Abnormal results

Bence Jones proteins are present in50-80% of people with multiple myeloma. People with other malignancies also can have a positive Bence Jones proteins test, but less frequently.

Certain nonmalignant diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and chronic renal insufficiency, can have Bence Jones proteins in the urine. High doses of penicillin or aspirin before collecting the urine can give a false positive result.

Resources

Books

Pagana, Kathleen Deska. Mosby's Manual of Diagnostic and Laboratory Tests. St. Louis: Mosby, Inc.,1998.

samah morsal
by samah morsal , اخصائى ثانى مختبرات طبيه , القوات المسلحة السودانيه

  • نتيجة لانخفاض قدرة الكلى على الفلترة نتيجة للقصور الكلوى الناتج عن ارتفاع نسبة الكالسيوم فى الدم  نتيجة لتحرر الكالسيوم من تاكل العظام نتيجة النشاط الورمى 

Dalal Elkaffash Elkaffash
by Dalal Elkaffash Elkaffash , المشرف العام على معامل قسم الباثولوجيا الاكلينيكية و المدير التنفيذي لمعمل البيولوجيا الجزيئية , كلية الطب - جامعة الاسكندرية

يتكون بروتين بنس جونز من السلاسل الخفيفة (كابا و لامدا) للاجسام المضادة (الجلوبيولين المناعي)و الذي يفرز من الخلايا البلازمية الغير طبيعية في الورم النقوي المتعدد.

Sami Mohamed
by Sami Mohamed , medical lab director (senior Specialist) , vein medical laboratories

بنس جونس بروتين عبارة عن بروتين صغير جدا ينتج دايما من تحطم احد اللايت جين المتواجدة في الايمنوقلوبيلين التي تفرزها خلايا البلازما ونسبتة لصغره يتخطي الكليه ويظهر في البول او نتيجة للفشل الكلوي .

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