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It mostly depends on the Zone. If the zone have multiple exposed walls than it is better to take it multiple zones to know which specific area needs more cooling. For example a big area with 4 exposed walls and one wall is totally glass and on the south west orientation than this area will require more cooling than other area in same zone.
Similarly if there are uniform heating source in area with no exposed wall at all than i prefer to take single zone since all area within same zone will have uniform cooling requirement
In Middle East or In My organization generally they are using to split the large zone into multi split zone to better heat transfer i.e to achieve cooling in very short span of time. if we considered it a single zone than it ill take some times to feel cool at that particular space or zone. but apart in other parts of the world they ill not considered multi split zones except in some cases such as server room ,electrical room and many more similar example.
