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entropy is the state of material molecules whether they are open or closed systems
Entropy is a physical notion which studies the "disorder" within systems, some of its notions recently led to a remarkable advances in various fields such as cosmology, geoscience, computer science...etc. Thus, it is neither a general advantage nor disadvantage property, it is a notion or set of notions like any other physical notion such as gravity. Then, if we can discuss the disadvantages of the universe´ properties we mean that we know other (better) universes without those properties which is not the case.We can only discuss disadvantages of a property for certain case, not generally (like disadvantage of the nuclear energy exploitation).Regards,