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It all depends on how you intend to use the phone. If you are big on multitasking and having the ability to operate dual screens, I highly recommend the Note 5. The S Pen allows you to access applications from the homescreen and write notes, save them, and recover them later on. It's a much better planned out phone, in my opinion. Samsung is releasing the Galaxy S7 in a couple of months and it is rumored to be a powerful piece of hardware. Yet, once again, no S Pen. That stylus is specific to the Note series. In essence, it is all about user preference.
