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for my view, acccording to my experince in electronics and mechatronics, before to use a product like softwere(SIMATIC STP7), You have to read the file of softwre, and read the content called readme, you will get how you can interface window 10, if does not work you have tosearch the comptible drivers
You can't, you need to instal vertuale machine .. Thank's
i think the best is to contact Siemens directly
https://support.industry.siemens.com/cs/start?lc=en-US
in other hand you can change in windows you can change compatibility by right click then compatibility the mood then select the old operating system
note this strategy might will not function all what the system can do