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If you've taken any supplements, then there will be a significant decrease in your muscle mass. However, if you've been training naturally, muscle mass WILL decrease but not as much as it would if you were taking supplements.
The human body loses muscle mass every two weeks if you haven't been training, but generally it will come back quicker than you expect. It won't take as long as it did to grow when you first started training.
Not really. You will loose like 2 weeks of your work in gym or even less. It will looks like you are not training for years for you, but when you come back, it will back at old form in like one or two weeks. :) Just try to look what you are eating, keep it well and everything wont be bad :)