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To change to Task manager or log in or restart .
Ctrl+Alt+Del is known as the ("three-finger salute")[1][2][3] is a computer keyboard command on computers, invoked by pressing the Delete key while holding the Control and Alt key.
The function of the key combination differs depending on the context but it generally interrupts or facilitates interrupting a function.
Task manager, login option and user switch
To change the login ID or to restart the system and close the big file those are getting much ram and doing system slow.