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Both of them are Layer2 protocols, HDLC uses a differnt frames, and address structure frame travel from a DTE to DCE and acknowledgment are tranfered when the frames are received
in the case of frame relay DLCI -Data Link Circuit Identifier are used to itendify each point of a Link
therefre is an efficient frame handling mechanism are employed in frame relay and it is a faster service, the draw back is it needs Frame relay adaptors for communication.
HDLC can also be encapsulted in Frame relay thereby providing efficient networking capabilities.