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Hi,
I will assume you are talking about Hyper-v VMs, to take a backup of a VM you can use Veeam Backup & Replication v7 or Symantec Backup Exec.
Note that in Hyper-v2012 you can use the Hyper-v replication feature which allow you to make a copy of your VMs on different Hyper-v server, you can use these replicated VMs as a backup and as a DR.
HTH
Best Regards,
Veem backup and replication is good product.
Veeam backup and replication would be best choice for Hyper-V and VMware based VMs. Even it supports mailbox level backup for Exchange server VMs.
Symantec Backup Exec. is the best , but we can use Veeam , Acronix or use some regular ways like Clone VM or Template .