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Windows Update is up to date / AntiX / Firewall / less priviliges
The server should be in secure and protected network
Install Anti-virus as a separate server after the firewall device, configure in maximum safety and impose a policy on the entire network for ports that will only open from the firewall as a safety precaution as well as mail server fo email attachment, domain name restrictions and email spaming.
Keep it behind the firewall and Open only specific ports which are being used by the applications.