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The creativity there has no rules, on the web you can do what you need by choosing your sizes, but you should care that you deliver your message from the sizes you choose, the sizes can tell how much this words is important and the same for print as i think.
so try to test it before you publish it. this is the rule take you to success with anything.
Font Size should based on Line Hight and container width so user won't feel any destruction during reading , Normally for Web14px is standard font size.
Chris Pearson write a excellent article regarding Golden Ratio of Typography its must read item http://www.pearsonified.com/2011/12/golden-ratio-typography.php
It depends on the font, but12 is the normal size.
Most Often10px to12px is best for printed documents and web design.
10 to11 points