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Technology (hardware and/or software)
Globalization
Competition
Customers
Demographics
Lifestyles
Psychographics (consumer sentiment)
Firmographics (business sentiment)
Economy
Regulatory practices
Business practices
Limitation of resources like time, money and availability of organization resources are some of the difficulties you may face as a sales person. Precious time can be wasted either on the wrong clients or on the incorrect people among the potential clients.