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Nadim Daher , Network & System Administrator , Menacom Group
Configuring ISA server is not a1 click issue to do.
You need to know your network infrastructure, requirements and plan for the installation.
To prevent long discussing over Bayt.com, This below link will provide you with the configuration step for ISA2006. If you are using another version let me know.
http://www.nappliance.com/support/library/mISA-mISAE/ISAE_Configuring%20ISA%202006EE%20Array-1.0.pdf
GoodLuck.