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Zollinger-Ellison syndrome (ZES) is
an endocrinopathy characterised by gastrin-secreting tumours, which cause multiple, refractory and recurrent peptic ulcers in the distal duodenum and proximal jejunum. There are two main variants:
Sporadic (isolated).
Associated with parathyroid and pituitary tumours as part of the genetic disorder .
The tumour (gastrinoma) is usually in the duodenum (60-65%) or the pancreas (30%). In rare cases, gastrinomas occur in other abdominal locations (eg, the stomach, liver, bile duct, ovary) and also extra-abdominal locations (eg, the heart, lung - small cell lung cancer)
Zollinger-Ellison syndrome is a complex condition in which one or more tumors form in your pancreas or the upper part of your small intestine (duodenum). These tumors, called gastrinomas, secrete large amounts of the hormone gastrin, which causes your stomach to produce too much acid. The excess acid, in turn, leads to peptic ulcers.
