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Prevention of Nitroglycerin Tolerance is by providing a nitrate-free interval ( time of absence of nitrates in the body )each day :
if the patient is using short-acting preparation : the last dose should be no later than7 pm to allow of- hours of nitrate-free period AND the frequency of dosing should be2-3 times/day not4 times/day
if the patient is using long-acting preparation : the frequency is twice a day so the recommendation will be to take the1st dose foe example at8 am , the second at2 pm to allow - hours of free interval of nitrates
the exact time should be suitable for the patient lifestyle.
In addition vitamin C can help in the prophylaxis of Nitrate tolerance.
