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In writing, what actually makes a best seller is the title of the writing as well as the content of such writing.
It depends on you, the author. How you present your work is what matters most. If your presentation of facts or data is cluttered and don't make sense, or if you are uncertain about your target audience, then just expect that your work will just be tossed away by your prospective readers.
Anything that is creative-sells. So a best seller has to be truly creative and outstandingly novel!