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every programming language has a good framework but i think for Python the FLASK framework is better, well Pythonista describe it as a micro-framework not because it is not powerful but because it use the notation of extensions, you have the framework without a lot of tools so you can use it easy and once you want to use a feature let's say you want to use SQLite then you can add it easy so the farework give you the power to choose your tools and it support a lot of technologies
I have used MyGeneration ORM, having clear mapping between your DB entities and business Objects
My best Framework web developer is Symfony 2, In fact it's provides a clear architecture MVC with nice and best view coding.