You can freeze the layer in the current viewport when the layout viewport is active?

Correct answer is already here,. Anyways thank you for your invitation..

the answer is true 100% ///////////////////////////////////////

absolutely true.............................................................

You can access model space from a layout viewport to edit objects, to freeze and thaw layers, and to adjust the view.

true,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,

Answer . False

I apologize for the answer I leave the answer to the experts, specialists in this field.