What is the difference between 5S and SIX SIGMA.?

For Six Sigma, 5S can be invaluable for reducing waste. High-performing processes and workplaces are always characterized by organization and cleanliness. The whole point is to reduce or keep out waste, and the method that helps you with that is called 5S.

Five S is a manageable process that is relatively easy for people to understand and get their arms around. Five S is a reference to five Japanese words that have been transliterated and translated into English. The technique is often characterized, incorrectly, as a “standardized cleanup.” It is more than that. Five S is a method to organize and manage the workspace and work flow with the intent of improving efficiency by eliminating waste, improving work flow and reducing process inefficiencies. The 5S’s are: Sort (Seiri), Straighten (Seiton), Sweep (Seiso), Standardize (Seiketsu) and Sustain (Shitsuke).

Six Sigma is a quality improvement technique developed by Motorola in 1986 to improve manufacturing processes and eliminate defects.  Six Sigma has two key methods – DMAIC (used in existing processes) and DMADV (used in new products/processes).

they're not two completely different things. However, both can be used in continuous improvement programs, in organizations to drive efficiency. But you already know that :) 

i see 6 Sigma more of Statistical approach for DMAIC: Define-Measure-Analyze-Improve-Control

while 5S more of "On Floor" activity that you can teach easily even to kids in their rooms