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Difficult people do exist at work. They come in every variety and no workplace is without them. How difficult a person is for you to deal with depends on your self-esteem, your self-confidence, and your professional courage.
Dealing with difficult people is easier when the person is just generally obnoxious or when the behavior affects more than one person. Dealing with them is much tougher when they are attacking you or undermining your professional contribution.
The best way is to confront them directly on how they effect your work. If that doesn't help then request a formal meeting with your boss and the individual. If you still don't get results the next step is to go to HR. Make sure you document everything.