In google adwords what must be done on this case?

It is necessary to specify the region in targeting settings, for example Spain

Hi. As mentioned by you that you ship to customers all ober the world and also thay you want to serve Spanish Language users for this you should first find out the spanish speaking countries. Target this countries and select spanish in language and creat ads in Spanish. You can create one campaign with the above mentioned setting. Second campaign you can create using all the countries and selecting only spanish as the language and creating spanish ads. You can test both the campaigns and see which is performing well and continue with it. Try only using Serch campaigns if you have budget constraints.

yes. Targeting option should be redefine... but it will change in display network

Google Adwords allow you to target specific countries and even languages. Geo targeting should be selected to spain and no other locations should be checked, same with the case of language. Make sure however that the ads can be read and understood by your targetted audience.

You should target people who speaks this language

AdWords (Google AdWords) is an advertising service by Google for businesses wanting to display ads on Google and its advertising network. The AdWords program enables businesses to set a budget for advertising and only pay when people click the ads. The ad service is largely focused on keywords.

Broad Match: This reaches the most users by showing your ad whenever your keyword is searched for.

Negative Match: This option prevents your ad from showing when a word or phrase you specify is searched for.

Phrase Match: Your ad is shown for searches that match the exact phrase.

Exact Match: Your ad is shown for searches that match the exact phrase exclusively.