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It depends mainly on the depth of concrete box girder related to the width of the bridge, if the box girder depth > 1/6 bridge width so it shall be designed as single cell and vise versa in case it's less than 1/6 of the bridge width.
Athough this not in my specialist and after i read:
But the princible to carry the wieght load from a point inidefference as to whether the pending moment in positive and negative forc to there torsional stafness from the point of view of economy.
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