How to enhance dissolution profile of a poorly water soluble API?

Question

venkatarao polina · Answer

To improve the solubility with nanocrystalization by antisolvent.

Seyyed Amir Siadati · Answer

1. you could heat (if the heat does not decompose the matter) or ultrasound the sample solution.

2. you could decrease the concentration of the test solution.

3. or if possible, you could reject the solubility test due to certificate, and then say the project manager to make a new "poly morph" (or a powder with smaller crystals) of the matter by recrystallization.

mohammed irfan · Answer

We have to check its it's solubility on 0.0001N HCl if not then 0.001N HCl,then 0.01 N HCl and finally 0.1N HCl if

jayasutha iyyapaazham · Answer

SALT FORM OF DRUG,COSOLVENT,SOLID DISPERSION

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How to enhance dissolution profile of a poorly water soluble API?

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