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Primavera
The software must be universal and standard which the project include some people specialist in this field .
Select software that can talk (integrate) with other vital applications in your organization like ERP to have project information seamlessly integrated and available for your decision as a PM or Executive. Primavera is integrable with SAP and ORACLE.
As world wide use , First Oracle , Second SAP , third Great Plains , It depends on the company Budget and the best use of it throught all the company employe as well.
For big project, i advise Primavera Enterprise.
First thing to do with one big project: break it down into smaller projects, and break them again into stages to be developed in time and the problem becomes less complex. This is common practice for instance if one has to implement for instance a supply chain with back orders, like in pharmacies or clothing...this should reduce the software requirements and the irrespective costs because in large projects it's necessary to have tailored solutions.