Do you think that doing business in the Middle East is more difficult than in other regions like Europe or the US, for example?

Yes , Specialy for strategic business planning due to information scarcity about the main market  players ,  shortage in macro / micro Statestics , and absence of governemental tranceparancy .

Cerainly;The Environment differentiates in accepting business style and products lack of resources to be more specific "Humanitarian resources:

No, I dont think so........

whene you have the money & experience, it will be same.