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As far as centralised operations are concerned; all the red flag and positive/false alerts are supposed to be reported to your AML / Compliance team to provide approval to release such payments.
Once AML/Sanction unit provide the clearance then release the payment.
I am working with "Fircosoft - PEP compliance
we are uploading the payment to the swift payment system, before uploading the file, FinScan watch list filtering the payments, Matching payments are automatically blocked by finscan, Then each and every blocked payment manually assessed whether release or reject