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It depends :-)
ArcGIS Desktop10.2.1 the latest and best
ESRI products are the best GIS software.
At present arcgis10
Esri software programs are the best as they are known to be flexible and use friendly. Arc Map10.2, is the best and latest program.
Sadly, the truth is that Is the best for what client WANT is ArcGIS, while the best for what clients NEED is (A map API, Database and a server side script "I use php").
Remember that "There is no short fit all" ;)