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If I am talking to one person or small group of people .. I try to establish a foundation for what the talk will be about and what it aims to achieve . Here, I may have prior knowledge of the people that I talk to, which means little more comfort knowing who they are. If this is the first time and I have no previoius knowledge, then I will spend the first few minutes exploring what could be a good start point for the talk
Anither case which I am experienced with, is when you address a public audience and talk to them about some common intersst topic (as in conferences, seminars, presentatons, ...) . Here, you have no control on who the audience are, and there may be no prior knowledge of who the audience are. However , the topic itself will determine to a large degree how you will address this audience and talk to them