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Reiterating few and adding more to what is mentioned earlier. Some of these apply to all software and not just those running on cloud
If you talking about Azure cloude service it has there own security.
1. Fence the system : Use of firewalls, packet filtering on nodes/devices facing the public. No nodes should be facing public except a reverse proxy which will pass the traffic to the front ends then to the application layers.
2. Use integrity checking software such as tripwire or rootkithunter
3. If possible use Antivirus Gateway as part of the public facing node.
4. Implement good auditing. Use tools such as splunk for logs inspection with proper log indexer and probably a dedicated node.
5. Have a disaster recovery plan - backups strategy, HA strategy.
In short its. Deter, Prevent, Detect , Correct.