How does one write true human interest stories based on "most significant change" principle?

Changes comes with time and environment so the most crucial,critical and successful topics are affecting human interest and could serve the most interest in any human core which could lead to an understanding of a given situation that can most define and be significant in mankind.

It depends on the writer how he/she makes a topic interesting to read.  A good writer can even make a very trivial story interesting.  The key element here is CREATIVITY - how you present the story to make the reader drawn into it.

This is done by experience the situation you want to write it downand put the key point sand then access to the writing style closer to the truth because it would be closer to the mind and heart together