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What are Heinz bodies?

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Question ajoutée par Ahmed Barhoom , موظف ومدرب , مختبر برهوم المركزي
Date de publication: 2014/06/15
Mohamed  shaheen
par Mohamed shaheen , مدرس كلينيكال باثولوجي , كلية الطب جامعة الأزهر

Heinz bodies appear as small round inclusions within the red cell body, though they are not visible when stained with Romanowsky dyes. They appear more clearly when supravitally stained

Heinz bodies (also referred to as "Heinz-Ehrlich bodies") are inclusions within RBCs composed of denatured Hb.  

Utilisateur supprimé
par Utilisateur supprimé

Heinz bodies are inclusions in red blood cells, they are caused by the denaturation of haemoglobin. Heinz bodies can be seen in cases of haemolytic anaemia.

Waleed Libda
par Waleed Libda , S.Medical Technologist , Weyburn General Hospital

Heinz bodies are cellular inclusions in a red blood cell that consists of damaged aggregated hemoglobin seen in patients with drug-induced oxidative damage, G6PD deficiency, unstable hemoglobins and with some forms of hemolytic anemia. “Bite cells” may be seen; produced by removal of Heinz bodies from red cells with damaged membranes by splenic macrophages. Heinz bodies are not visible on a Wright-Giemsa stain, must be visualized using supravital stains (e.g., methyl violet, crystal violet, brilliant green, or new methylene blue).

Nabil Hijazi
par Nabil Hijazi , Director , Biocell Lab

Heinz bodies are formed by damage to the hemoglobin component molecules, usually through oxidant damage, or from an inherited mutation (i.e. change of an internal amino acid residue). As a result, an electron from the hemoglobin is transferred to an oxygen molecule, which creates areactive oxygen species(ROS) that can cause severe cell damage leading to premature cell lysis.Damaged cells are cleared bymacrophagesin thespleen, where the precipitate and damaged membrane are removed, leading to characteristic "bite cells". The denaturing process is irreversible and the continual elimination of damaged cells leads toHeinz body anemia.

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