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In my opinion, If you feel more stress & loosing your concentration from your work then its time to take some rest.
fatigue, loss of concentration, loss of interest, stress, muscle ache and depression.
We must thank to the wonderful engeneering of our body done by almighty god.
When you body shows the stress signs, it means its a rest time.
when you feel less love for your work
When getting up in the morning and getting ready for work seems like the worst punishment one could suffer.
If you're forgeting your self worth.
Dear,
There's a lot of sign(s), i.e borring, loss of energy,loss of control, .....mistakes.................& the most important thing is there's no new ideas..............
When routine work taking more time and energy than used to be. Time to get break ...
after6 months if you just joined an organization, i believe you can ask for a break.
and answering your question; it will be once you feel exhausted or you're not able to give like before.
this means you're in a need for refreshment
When you are unable to think out of the BOX and continuesly forgetting your daily tasks, then it is a time be off from work for a short period to relax with family.
Any time off must be inline with business conditions.